abstract：:To assess the efficacy of CM40907--a new antiepileptic drug--in suppressing inter-ictal spikes, 6 patients with severe intractable epilepsy and frequent spikes in their inter-ictal EEGs were entered in a double-blind placebo-controlled trial. The results show that CM40907 is efficacious in reducing spike counts in the...

journal_title：Epilepsy research

authors： Yepez-Lasso R,Duncan JS,Shorvon SD

更新日期：1990-04-01 00:00:00

abstract：:A single-dose study of the beta-carboline, ZK 95962, on photosensitive generalized paroxysmal activity in the EEG was conducted in 6 patients with primary generalized epilepsy. Four of the patients were newly diagnosed and did not receive any antiepileptic drug or other medication during the study. Two were receiving ...

journal_title：Epilepsy research

authors： Møller A,Jensen LH,Skrumsager B,Blatt-Lyon B,Pedersen B,Dam M

更新日期：1990-03-01 00:00:00

abstract：:The present study used Nissl stains and glutamate decarboxylase immunoreactivity (GAD-IR) to quantify the acute and chronic toxicity of kainic acid (KA) on focal and remote hippocampal principal neurons (i.e., pyramidal and granule cells) and on putative inhibitory neurons (GAD-IR or GABAergic) following intrahippocam...

journal_title：Epilepsy research

authors： Davenport CJ,Brown WJ,Babb TL

更新日期：1990-01-01 00:00:00

abstract：:Biochemical studies have indicated that norepinephrine is present in lower levels in certain brain regions of genetically epilepsy-prone rats (GEPR-9s) as compared to non-epileptic Sprague-Dawley (SD) rats. In this study, the immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthesizing enzyme f...

journal_title：Epilepsy research

authors： Lauterborn JC,Ribak CE

更新日期：1989-11-01 00:00:00

abstract：:The effects of systemic pretreatment with morphine sulfate (MS) on electroencephalographic (EEG) manifestations of seizures due to bicuculline (BIC) were studied in freely moving rats. Electrodes were placed on frontal and occipital cortices, into the hippocampus and into a region of the prepiriform cortex, area tempe...

journal_title：Epilepsy research

authors： Massotti M,Gale K

更新日期：1989-09-01 00:00:00

abstract：:The effect of repetitive administration of naloxone on the development of massed amygdaloid kindling in 'encéphale isolé' cats was studied. Electrical amygdaloid kindling was carried out with a 15 min inter-stimulus interval (ISI) in a control situation with intravenous (i.v.) naloxone administration (2, 4, and 8 mg/k...

journal_title：Epilepsy research

authors： Fernández-Guardiola A,Rocha L,Pellicer F,Gutiérrez R,Calvo JM

更新日期：1989-07-01 00:00:00

abstract：:In rats with electrodes implanted in the hippocampus or amygdala, the effect was studied of a single episode of low frequency stimulation (125 msec, biphasic 4 Hz, for 1 min at a current 50% of threshold for after-discharge), LFS, on the after-discharge thresholds (ADTs) during the course of hippocampal and amygdaloid...

journal_title：Epilepsy research

authors： Ullal GR,Ninchoji T,Uemura K

更新日期：1989-05-01 00:00:00

abstract：:Dogs were treated with clorazepate, which is known to be completely metabolized to desmethyldiazepam. 2 mg/kg t.i.d. were given orally for 5-6 weeks, a dose regimen providing plasma concentrations of desmethyldiazepam in the range known to be therapeutic in man. The rate of development of tolerance to the anticonvulsa...

journal_title：Epilepsy research

authors： Scherkl R,Kurudi D,Frey HH

更新日期：1989-03-01 00:00:00

abstract：:Basal and high potassium-stimulated release of endogenous amino acids was measured using brain dialysis in the hippocampus of urethane-anesthetized seizure-resistant (SR) and seizure-susceptible (SS) rats. Moreover, the tissue level of amino acids was determined in the hippocampus, sensorimotor cortex, cerebellum and ...

journal_title：Epilepsy research

authors： Lehmann A

更新日期：1989-03-01 00:00:00

abstract：:Two hundred and thirty-five patients suffering from newly diagnosed epilepsy were randomly allocated to treatment with either oxcarbazepine or carbamazepine in a double-blind multi-centre study. After a titration phase (between 4 and 8 weeks), the optimal individual dose of trial medication was determined and treatmen...

journal_title：Epilepsy research

authors： Dam M,Ekberg R,Løyning Y,Waltimo O,Jakobsen K

更新日期：1989-01-01 00:00:00

abstract：:The severe seizure genetically epilepsy-prone rat (GEPR-9) is characterized by a broad-based seizure predisposition and is increasingly recognized as a useful model of epilepsy. When sound stimulated, members of the GEPR-9 colony exhibit complete tonic extensor convulsions. Female GEPR-9s appear to experience a higher...

journal_title：Epilepsy research

authors： Mishra PK,Dailey JW,Reigel CE,Tomsic ML,Jobe PC

更新日期：1988-09-01 00:00:00

abstract：:Daily treatment of mice with diazepam leads to the development of tolerance to the anxiolytic and anticonvulsant effect of the benzodiazepine, while daily treatment with the proconvulsant benzodiazepine receptor inverse agonist FG 7142 produces sensitization to its effects in that seizures develop (chemical kindling)....

journal_title：Epilepsy research

authors： Löscher W,Stephens DN

更新日期：1988-07-01 00:00:00

abstract：:Valproate (VPA) and vigabatrin (gamma-vinyl GABA, GVG) are two novel antiepileptic drugs with a presumed GABAergic mechanism of action. However, for VPA, this aspect has been extensively debated. The aim of the present study was to investigate whether treatment of cultured neurons with clinically relevant concentratio...

journal_title：Epilepsy research

authors： Gram L,Larsson OM,Johnsen AH,Schousboe A

更新日期：1988-03-01 00:00:00

abstract：:Secondarily generalized convulsive status epilepticus was induced by intraperitoneal (i.p.) injection of D,L-homocysteine thiolactone to rats with actively epileptogenic cobalt lesions in motor cortex. This induced focal motor seizures which secondarily generalized. Control animals not treated with antiepileptic drugs...

journal_title：Epilepsy research

authors： Walton NY,Treiman DM

更新日期：1988-03-01 00:00:00

abstract：:The purpose of this investigation was to inquire into the multietiological determinants of psychopathology and social competence in children with epilepsy. The relationship between behavioral functioning as assessed by the Child Behavior Checklist and a variety of biological, psychosocial, medication and demographic r...

journal_title：Epilepsy research

authors： Hermann BP,Whitman S,Hughes JR,Melyn MM,Dell J

更新日期：1988-01-01 00:00:00

abstract：:We have surveyed the rates at which clinicians in the U.K. and Eire withdraw antiepileptic drugs (AEDs) in patients with active epilepsy. Practice differed widely and there was a lack of consensus regarding the rates employed. Inpatient reductions were 2-4 times faster than outpatient reductions. AED reductions tended...

journal_title：Epilepsy research

authors： Duncan JS,Shorvon SD

更新日期：1987-11-01 00:00:00

abstract：:Twenty-one children (11 boys, 10 girls) suffering from visual seizures were studied. The visual seizures manifested as loss of vision, flickering light, blurring or figurative hallucinations. Ictal EEGs during visual seizures were recorded in 4 cases; the ictal discharges all originated in the occipital area. Visual s...

journal_title：Epilepsy research

authors： Aso K,Watanabe K,Negoro T,Takaesu E,Furune A,Takahashi I,Yamamoto N,Nomura K

更新日期：1987-07-01 00:00:00

abstract：:Interactions of subclinical epileptiform EEG discharges and cognitive functioning were studied in 91 patients with epilepsy, under video monitoring, to exclude overt clinical ictal phenomena during the investigations. A short-term memory test was presented as an engaging television game, in two versions, using spatial...

journal_title：Epilepsy research

authors： Binnie CD,Kasteleijn-Nolst Trenité DG,Smit AM,Wilkins AJ

更新日期：1987-07-01 00:00:00

abstract：:Spontaneous recurrent seizures (SRSs) were observed in female rats following the injection of kainic acid into the dorsal hippocampus. Pregnancy and nursing decreased the frequency of SRSs in such animals. The finding of a protective effect of pregnancy and lactation in this animal model of temporal lobe epilepsy stre...

journal_title：Epilepsy research

authors： Berzaghi Mda P,Amado D,Cavalheiro EA

更新日期：1987-03-01 00:00:00

abstract：:Burst structure and synchronized firing of bursts were studied, in the interictal period, using auto- and cross-correlation analyses in human amygdala neurons in temporal lobe epilepsy patients diagnosed as having a unilateral limbic seizure focus in anterior hippocampus and/or amygdala. Satisfactory single unit recor...

journal_title：Epilepsy research

authors： Isokawa-Akesson M,Wilson CL,Babb TL

更新日期：1987-01-01 00:00:00